CAG CAG CAG CAG CAG...
in molec bio we were talking about genomes and karyotypes.
have you heard of huntington's disease?
in huntington's disease you have repeating sequences of CAG (as in nucleotide bases) in the middle of chromosome 4.
when DNA is being replicated polymerase goes down the line... CAGCAGCAGCAGCAGCAGCAG... and then goes "oh shit, where was i? i'll just throw in another CAG for good measure." so everytime DNA is replicated more CAGs get thrown in.
and CAG codes for the amino acid, glucine. it's really sticky.
so tons of glucine is made in your cell. more than enough glucine is made.
and the cell gets so overloaded, it kills itself.
so you start to lose cells... which means losing neuro functions...
and you die before age 65.
if you have more than 28 repeating CAGs on your chromosome, you might be at risk. once you have 35 CAGs or more, you're pretty much served the death sentence.
mattT was like, you know, we could make a test for that. pcr the front end and back end of the CAG and measure it on a gel. we could find out if you're going to die sooner than later.
and then he said, NO WTF. WHY WOULD WE WANT TO DO THAT. THIS IS SO WRONG...
i vote yes. i'd want to know. i need to know.
what about you? would you want to know if you are going to die at 65?
hell, would you want to get a karyotype of your dna and see all the diseases you may encounter in your life time?
just my question to the world...
Transmission Received at 10/28/2009 02:14:00 PM
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